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The spectrum of diseases in which the use of NSAIDs. extremely wide. Along with rheumatic diseases (rheumatoid arthritis, ankylosing spondylitis, gout, etc.), it includes the pain of various origins (misoprostol buy online), as well as coronary heart disease. Use of these drugs clearly improves the quality of life for these patients. However, a significant increase in the consumption of NSAIDs has led to an increase in the incidence of side effects, primarily due to involvement of the gastric mucosa. These lesions are called "gastropathy. induced by NSAIDs. They identified approximately 70% of patients, systematically taking NSAIDs for six weeks or more. Subjectively gastropathy include nausea, sometimes vomiting, feeling of heaviness and pain in the epigastrium. abdominal distention, anorexia and other diarrheal disorders.

The most severe manifestations of gastropathy include erosive and ulcerative lesions of the mucous membrane of the stomach and duodenum, the frequency of ulceration in the stomach of an average of 20%. in the duodenum - 10%. On continued receiving NSAID gastroduodenal ulceration in 40% of cases are complicated by bleeding. The incidence of gastro-and duodenopatii, gastric and duodenal bleeding depends on the drug, its dose, duration of admission and some other factors.

The lowest risk of gastro-and duodenopatii complicated by bleeding, have ibuprofen (brufen and other synonyms) and diclofenac (voltaren and other synonyms), and the largest - azopropazon, ketorolac, piroxicam, tometil, phenylbutazone (phenylbutazone), aspirin, diflunisal, naproxen, and sulintsak occupy an intermediate position.

Risk factors for the development of gastro-and duodenopatii resulting from the use of NSAID therapy, and include: age over 60 years, peptic ulcer history, smoking, alcohol, co-administration of anticoagulants and glucocorticoids, a systematic method of NSAIDs for 6 weeks or more, use high doses of drugs that are 2 and 3 risk lesions of the mucous membrane of the stomach and duodenum, intramuscular injection of the drug misoprostol bought online
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